Insulin Resistance and Acne: How Blood Sugar Impacts Your Skin

If you’re breaking out despite trying every cleanser, the root cause might not be on your skin—it could be in your blood sugar. Emerging research suggests that insulin resistance and high-glycemic diets play a key role in hormonal acne. When your body doesn’t respond effectively to insulin, it compensates by producing more of it, triggering cascades of hormones and growth factors that increase oil production and inflammation in the skin. In this article, we’ll explore how blood sugar regulation affects acne, review evidence linking insulin resistance to breakouts, and explain how testing your biomarkers can help you target this hidden driver.

What Is Insulin Resistance?

Insulin is a hormone produced by the pancreas to help cells absorb glucose from the bloodstream. Insulin resistance (IR) occurs when cells become less responsive to insulin’s signal. To maintain normal blood glucose, the pancreas produces more insulin. Over time, this leads to chronically high insulin levels—a state called hyperinsulinemia. Hyperinsulinemia can increase the production of other hormones and growth factors, including insulin‑like growth factor‑1 (IGF‑1) and androgens, which have direct effects on sebaceous (oil) glands and skin cells. IR is a central feature of metabolic syndrome and is also common in polycystic ovary syndrome (PCOS), where it contributes to elevated testosterone levels and persistent acne.

How High Blood Sugar and Insulin Influence Acne

High‑Glycemic Foods Spike Insulin

The glycemic index (GI) and glycemic load (GL) measure how rapidly a food raises blood sugar and insulin levels. Diets high in refined carbohydrates—such as white bread, cornflakes and white potatoes—cause rapid spikes in blood glucose and insulin. According to Yale Medicine, high‑glycemic‑load foods may contribute to the development or worsening of acne. Conversely, low‑GI diets, rich in whole grains, legumes and vegetables, produce smaller insulin surges.

Insulin, IGF‑1 and Androgens

Excess insulin stimulates the liver to produce more IGF‑1, a growth factor that increases cell proliferation and sebum production. It also prompts the ovaries and adrenal glands to secrete androgens (male hormones such as testosterone). Elevated androgens drive sebaceous glands to produce more oil and cause skin cells to shed more rapidly, clogging pores. Researchers note that hyperglycemic carbohydrates and insulinotropic milk products may promote acne pathogenesis by encouraging IGF‑1 signaling. Furthermore, insulin promotes androgen synthesis, resulting in excessive sebum production—a known correlate of acne severity.

Insulin Resistance and Acne Severity

Insulin resistance amplifies this cascade. A 2023 case–control study published in Cureus measured C‑peptide and triglyceride‑glucose (TyG) index levels (markers of insulin resistance) in acne patients and healthy controls. The researchers found that 81% of acne patients had insulin resistance based on C‑peptide levels and 67% based on the TyG index, compared with only 27% and 19% in controls. They also observed a strong positive correlation between insulin resistance biomarkers and acne severity, suggesting that higher insulin resistance predicts more severe breakouts.

Evidence Linking Diet, Insulin and Acne

Multiple studies and clinical observations highlight the connection between diet, blood sugar and acne:

• High‑Glycemic Diets: Several reviews and observational studies report that high‑glycemic diets are associated with more acne lesions. This may be due to spikes in insulin and IGF‑1, which stimulate oil production and skin cell proliferation. Yale Medicine notes that high‑glycemic foods like white bread and cornflakes raise blood sugar quickly and may exacerbate acne.

• Dairy Products: Insulinotropic milk and dairy products also trigger insulin and IGF‑1 release. One review explained that milk may promote acne by increasing IGF‑1 signaling.

• Insulin Promotes Androgens: Elevated insulin directly stimulates androgen production. Androgens increase sebum production and cause thicker keratin plugs in hair follicles, making breakouts more likely.

• Low‑GI Diets Improve Acne: The same study noted that low‑glycemic diets improve acne severity and insulin sensitivity in young males. Anecdotally, many patients report clearer skin after reducing refined carbs and sugars.

• Weight and Metabolic Factors: Obesity and metabolic syndrome correlate with both insulin resistance and acne severity. In PCOS, dietary restriction, exercise and weight loss reduce insulin resistance and testosterone levels, helping control metabolic and hormonal features of the condition.

These findings suggest that controlling blood sugar and improving insulin sensitivity may be key for managing hormonal acne—especially in individuals with persistent or adult-onset acne.

Signs You Might Have Insulin‑Related Acne

Not everyone with acne has insulin resistance, but certain clues can suggest a blood‑sugar component:

• Persistent breakouts despite skincare – If you’ve tried topical treatments and still have moderate to severe acne, especially along the jawline or cheeks, insulin resistance could be contributing.

• Cravings and energy crashes – Frequent cravings for sweets and refined carbs, followed by energy slumps, indicate unstable blood sugar.

• Central weight gain – Fat accumulation around the abdomen is common in insulin resistance and PCOS.

• Skin tags and darkened neck creases – These signs, along with acanthosis nigricans (dark patches on the skin), can signal insulin resistance.

• Family history of diabetes or PCOS – Genetics and family history can predispose individuals to insulin-related issues.

If you identify with these symptoms, consider discussing insulin resistance with your healthcare provider or exploring targeted testing.

How to Improve Insulin Sensitivity and Support Clear Skin

While everyone’s biology is different, evidence suggests several strategies for improving insulin sensitivity and reducing acne flares:

1. Adopt a Low‑Glycemic Diet

Focus on foods that release glucose slowly into the bloodstream. This includes:

• Whole grains: Quinoa, brown rice, oats and barley.

• Legumes: Lentils, chickpeas and black beans.

• Non‑starchy vegetables: Leafy greens, broccoli, bell peppers and zucchini.

• Low‑sugar fruits: Berries, apples and pears.

• Healthy fats: Avocados, nuts, seeds and olive oil.

Reduce or avoid foods that spike blood sugar, such as sugary beverages, pastries, candy, white bread, white pasta and processed snacks.

2. Balance Protein and Fiber

Protein and fiber slow the absorption of glucose and keep you feeling full longer. Include lean proteins like fish, poultry or tofu with each meal, and add fiber‑rich vegetables, fruits and whole grains. This combination minimizes blood sugar swings and helps regulate appetite.

3. Incorporate Regular Physical Activity

Exercise increases insulin sensitivity by helping muscles absorb glucose more efficiently. Aim for a mix of aerobic activity (brisk walking, cycling, swimming) and strength training. Even moderate exercise, such as a 30‑minute walk after meals, can make a difference.

4. Manage Stress and Sleep

Chronic stress raises cortisol, which can worsen insulin resistance and stimulate oil production. Practice stress‑reduction techniques like yoga, meditation, breathing exercises or journaling. Prioritize 7–9 hours of quality sleep; sleep deprivation disrupts hormones that regulate blood sugar and appetite.

5. Maintain a Healthy Weight

Excess body fat, especially around the abdomen, contributes to insulin resistance. Weight management through diet, exercise and lifestyle changes can significantly improve insulin sensitivity. Research in PCOS demonstrates that dietary restriction, exercise and weight loss reduce insulin resistance and testosterone levels.

6. Consider Strategic Supplements

Certain nutrients support insulin sensitivity and skin health. These include:

• Chromium and magnesium, which play roles in glucose metabolism.

• Omega‑3 fatty acids (from fish oil or algae), which reduce inflammation.

• Zinc and vitamin D, common deficiencies that can exacerbate hormonal acne.

Always consult a healthcare professional before starting supplements, especially if you’re on medication or have underlying health conditions.

Why Testing Your Blood Sugar and Hormones Matters

Dietary changes can help many people, but they may not be enough for everyone. Because acne is multifactorial, you might also have elevated androgens, cortisol imbalances or nutrient deficiencies. That’s why biomarker testing is a game‑changer:

• Identify insulin resistance early: Standard blood tests like fasting glucose, fasting insulin and HOMA‑IR (homeostatic model assessment of insulin resistance) reveal whether your body is struggling to regulate blood sugar. Advanced markers like C‑peptide and the TyG index can provide deeper insights.

• Assess hormones: Measuring testosterone, DHEA, estrogen and progesterone levels shows whether androgens are elevated or if other hormonal imbalances are at play.

• Check stress hormones: Cortisol patterns can indicate chronic stress or adrenal dysfunction, both of which influence insulin sensitivity and skin health.

• Detect nutrient deficiencies: Low levels of vitamin D, zinc and other micronutrients can worsen inflammation and metabolic health.

Having a comprehensive picture of your internal environment allows you and your healthcare provider to tailor an acne‑management plan—rather than guessing which diet or supplement to try next.

How the Acne Root Cause Test Can Help

BreakoutLabs’ Acne Root Cause Test offers an at‑home solution for people who suspect insulin resistance or other hormonal drivers behind their acne. This CLIA‑certified kit measures:

1. Hormones: Testosterone, estrogen, progesterone and DHEA—revealing hyperandrogenism.

2. Metabolic markers: Fasting insulin and glucose to calculate insulin resistance; C‑peptide and other advanced markers to evaluate metabolic health.

3. Stress hormone: Cortisol, identifying chronic stress that can worsen insulin resistance and oil production.

4. Nutrient levels: Vitamin D and zinc to uncover deficiencies that may exacerbate inflammation and metabolic dysfunction.

After sending your samples to the lab, you’ll receive a personalized Clear Skin Blueprint™. A licensed physician reviews your results and outlines specific dietary, lifestyle and supplement recommendations to improve insulin sensitivity and hormonal balance.

Conclusion: Get Ahead of Insulin‑Related Acne

While genetics and hormones play a role in acne, mounting evidence shows that blood sugar and insulin levels can greatly influence breakouts. High‑glycemic foods spike insulin; insulin stimulates androgens and IGF‑1; these, in turn, increase oil production and inflammation. Case–control research found that over 80 % of acne patients had insulin resistance, and high insulin levels were strongly correlated with acne severity. High‑glycemic diets and insulinotropic foods may worsen acne, while low‑glycemic diets and improved insulin sensitivity can lead to clearer skin.

If you suspect insulin resistance is playing a part in your acne, you don’t have to guess. By adopting a balanced diet, staying active, managing stress and testing your biomarkers, you can target the root causes of your breakouts. The Acne Root Cause Test gives you the data you need to personalize your approach and break free from endless trial and error.

Ready to understand how your blood sugar affects your skin? Order your Acne Root Cause Test today and start your journey toward clear, radiant skin from the inside out.